Troponin I Testing (TROPIG)

Reference range for troponin I

Concentration (ng/mL) Interpretation
< 0.04 Normal
0.04 - 0.39 Elevated above the 99th percentile of a healthy population.
≥ 0.40 Probable myocardial infarction.

Clinical Interpretation

The 99th percentile concentration for the Beckman AccuTnI assay implemented on January 21, 2014 is 0.03 ng/mL. According to current consensus guidelines (Newby 2012), troponin results that exceed the 99th percentile concentration are strongly suggestive of cardiac injury, which can be from many causes (see below for examples). For troponin concentrations 0.40 ng/mL and higher, the underlying cardiac injury is usually a myocardial infarction. Troponin concentrations of 0.04-0.39 ng/mL require serial troponin measurements and clinical correlation to interpret, as further described in the guidelines.

Partial list of non-ischemic causes of elevated troponin (myocardial damage)

Frequently Asked Questions Regarding the Use of Troponin

Adapted from Newby 2012, Table 3

What does an elevated troponin level mean?

When should a troponin level be obtained?

What is the prognostic significance of an elevated troponin level?

References

  1. Newby LK, Jesse RL, Babb JD, Christenson RH, De Fer TM, Diamond GA, Fesmire FM, Geraci SA, Gersh BJ, Larsen GC, Kaul S, McKay CR, Philippides GJ, Weintraub WS. (2012) ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American College of Cardiology Foundation task force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 60:2427-63.

chemistry/TROPIG (last modified 2015-10-30 15:28:04)